Adaptive bolus chasing computed tomography angiography: Control scheme and experimental results

In this paper, a new adaptive bolus-chasing control scheme is proposed to synchronize the bolus peak in a patient's vascular system and the imaging aperture of a computed tomography (CT) scanner. The proposed control scheme is theoretically evaluated and experimentally tested on a modified Siemens SOMATOM Volume Zoom CT scanner. The first set of experimental results are reported on bolus-chasing CT angiography using realistic bolus dynamics, real-time CT imaging and adaptive table control with physical vasculature phantoms. The data demonstrate that the proposed control approach tracks the bolus propagation well, and clearly outperforms the constant-speed scheme that is the current clinical standard.